![]() Patients were excluded in case of neoadjuvant treatment or incomplete surgical resection (R2).īasic baseline clinical, biological (i.e. No systematic preoperative imaging review was made at inclusion.Īll patients who underwent upfront curative intent resection for a PA were included. All cases have been discussed in MTBM, including a senior radiologist and a pancreatic surgeon, as now recommended by the consensus of the International Study Group of Pancreatic Surgery. Patients were screened with administrative coding and multidisciplinary tumor board meetings data (MTBM). We retrospectively included patients with upfront resected PA between Januand Decemin three tertiary French centers (Reims University Hospital, Amiens University Hospital, Strasbourg University Hospital) and in one private center (Reims Courlancy Clinic). ![]() This study evaluated the impact of TTS on OS, DFS and postoperative complication rate in patients who underwent upfront curative intent surgical resection of a PA. Shorter TTS may not allow to optimize prehabilitation but could improve carcinologic prognosis. ![]() Improving preoperative status-by means of biliary drainage, hemostasis correction, prehabilitation with nutritional and adapted physical activity interventions -is needed before surgery as complications are more frequent in unfit patients. Moreover, pancreatic resection is one of the most challenging surgery, with significant postoperative morbidity and mortality. ![]() To date, the impact of TTS on OS and disease-free survival (DFS) in patients diagnosed with resectable PA remains unclear. Time to surgery (TTS) has turned out to be a major prognostic factor associated with survival in several malignancies. One of the objectives studied in other cancers has been to reduce time to treatment by improving the organization of the care pathway. New perspectives are needed to increase both survival rates and quality of life for patients diagnosed with PA. Unfortunately, prognosis remains poor despite improvements in surgical technique, perioperative care, diagnosis accuracy, patient selection and more active chemotherapy regimen. This malignancy is expected to be the second leading cause of cancer-related death in Europe by 2030.įrench actual standard of care for resectable PA is upfront carcinologic surgery followed by adjuvant chemotherapy. Five-year overall survival (OS) rate is estimated below 8% (all stages combined). Pancreatic adenocarcinoma (PA) is one of the most aggressive digestive cancers. TTS seems to have no impact on OS, DFS and 90-day postoperative morbidity. Other delay cut-offs had no impact on OS or DFS. ![]() Patients in the higher delay group (> 14 days) had significantly more vein resections and endoscopic biliary drainage. 59 patients (35%) underwent an upfront surgery within 14 days. ResultsĪ total of 168 patients were included. We also analyzed survival depending on different delay cut-offs (7, 14, 28, 60 and 75 days). DFS for a 14-day TTS was the primary endpoint. TTS was defined as the number of days between the date of the first consultation in specialist care and the date of surgery. We retrospectively included patients who underwent upfront surgery for PA between Januand Decemfrom four French centers. This study evaluated the impact of time to surgery (TTS) on overall survival (OS), disease free survival (DFS) and postoperative complication rate in patients with upfront resected pancreatic adenocarcinoma (PA). ![]()
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